 |
 |
|
|
| 16/04/2021 | 22:00 | Cruz Azul | - | Deportivo Guadalajara | 0:1 (0:0) | |
| 17/04/2021 | 16:00 | Mazatlán FC | - | CF Pachuca | 0:2 (0:0) | |
| 16:00 | Atlas Guadalajara | - | Club Necaxa | 3:1 (0:0) | ||
| 18:00 | Pumas UNAM | - | Gallos Blancos | 3:2 (2:1) | ||
| 19/04/2021 | 22:00 | Deportivo Toluca | - | Santos Laguna | 1:0 (0:0) | |
| 22:00 | Club León | - | Atlético San Luis | 3:2 (1:2) | ||
| 23:00 | CF Monterrey | - | CF América | 1:1 (1:0) | ||
| 20/04/2021 | 01:00 | Club Tijuana | - | UANL Tigres | 0:1 (0:1) | |
| 01:00 | FC Juárez | - | Puebla FC | 1:2 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 15 | 11 | 3 | 1 | 33:7 | 26 | 36 |
| 2 |
|
Deportivo Guadalajara | 15 | 10 | 3 | 2 | 36:15 | 21 | 33 |
| 3 |
|
Atlas Guadalajara | 15 | 10 | 3 | 2 | 28:19 | 9 | 33 |
| 4 |
|
CF Monterrey | 15 | 9 | 3 | 3 | 37:16 | 21 | 30 |
| 5 |
|
Pumas UNAM | 15 | 8 | 4 | 3 | 22:16 | 6 | 28 |
| 6 |
|
CF Pachuca | 15 | 8 | 3 | 4 | 20:13 | 7 | 27 |
| 7 |
|
Deportivo Toluca | 15 | 7 | 5 | 3 | 15:12 | 3 | 26 |
| 8 |
|
Cruz Azul | 15 | 6 | 4 | 5 | 18:19 | -1 | 22 |
| 9 |
|
CF América | 15 | 5 | 6 | 4 | 21:20 | 1 | 21 |
| 10 |
|
Mazatlán FC | 15 | 4 | 5 | 6 | 12:20 | -8 | 17 |
| 11 |
|
Club Tijuana | 15 | 4 | 3 | 8 | 13:18 | -5 | 15 |
| 12 |
|
Santos Laguna | 15 | 3 | 5 | 7 | 18:25 | -7 | 14 |
| 13 |
|
Club León | 15 | 4 | 2 | 9 | 14:30 | -16 | 14 |
| 14 |
|
Gallos Blancos | 15 | 4 | 1 | 10 | 14:24 | -10 | 13 |
| 15 |
|
Club Necaxa | 15 | 3 | 4 | 8 | 13:26 | -13 | 13 |
| 16 |
|
Atlético San Luis | 15 | 2 | 5 | 8 | 17:30 | -13 | 11 |
| 17 |
|
Puebla FC | 15 | 2 | 4 | 9 | 12:22 | -10 | 10 |
| 18 |
|
FC Juárez | 15 | 2 | 3 | 10 | 13:24 | -11 | 9 |
| Playoffs |
