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| 1st(1st leg) | Atlas Guadalajara | - | CF Monterrey | 1:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Atlas Guadalajara | 2:1 (0:1) | ||
| 1st(1st leg): 10/12/2021 17:00 | 2nd (2nd leg): 14/12/2021 03:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | CF América | - | UANL Tigres | 2:1 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | CF América | 4:0 (0:0) | ||
| 1st(1st leg): 11/12/2021 02:00 | 2nd (2nd leg): 14/12/2021 01:00 | Winner: UANL Tigres | ||||
