1st(1st leg) Cruz Azul - UANL Tigres 0:4 (0:3)
2nd (2nd leg) UANL Tigres - Cruz Azul 4:0 (1:0)
1st(1st leg): 03/12/2021 18:45 2nd (2nd leg): 07/12/2021 01:00 Winner: UANL Tigres
1st(1st leg) Santos Laguna - Atlas Guadalajara 2:2 (0:0)
2nd (2nd leg) Atlas Guadalajara - Santos Laguna 2:1 (1:1)
1st(1st leg): 04/12/2021 00:00 2nd (2nd leg): 06/12/2021 18:00 Winner: Atlas Guadalajara
1st(1st leg) CF América - Deportivo Guadalajara 2:1 (2:0)
2nd (2nd leg) Deportivo Guadalajara - CF América 0:0 (0:0)
1st(1st leg): 04/12/2021 02:00 2nd (2nd leg): 06/12/2021 23:00 Winner: CF América
1st(1st leg) Club Tijuana - CF Monterrey 1:1 (1:0)
2nd (2nd leg) CF Monterrey - Club Tijuana 1:1 (1:1)
1st(1st leg): 04/12/2021 03:30 2nd (2nd leg): 07/12/2021 03:00