 |
 |
|
|
| 13/11/2021 | 00:00 | Club León | - | Atlético San Luis | 0:0 (0:0) | |
| 02:00 | Mazatlán FC | - | Deportivo Toluca | 0:1 (0:1) | ||
| 18:00 | Atlas Guadalajara | - | CF Pachuca | 2:1 (0:1) | ||
| 18:00 | Pumas UNAM | - | Puebla FC | 0:1 (0:0) | ||
| 22:00 | Club Necaxa | - | FC Juárez | 3:1 (0:0) | ||
| 23:00 | Gallos Blancos | - | Santos Laguna | 4:2 (2:2) | ||
| 14/11/2021 | 02:00 | CF América | - | UANL Tigres | 1:1 (0:0) | |
| 16/11/2021 | 01:00 | CF Monterrey | - | Deportivo Guadalajara | 2:1 (1:0) | |
| 03:00 | Club Tijuana | - | Cruz Azul | 4:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 16 | 14 | 2 | 0 | 50:7 | 43 | 44 |
| 2 |
|
CF Monterrey | 16 | 13 | 2 | 1 | 40:10 | 30 | 41 |
| 3 |
|
Atlas Guadalajara | 16 | 10 | 3 | 3 | 26:16 | 10 | 33 |
| 4 |
|
Deportivo Guadalajara | 16 | 9 | 3 | 4 | 31:17 | 14 | 30 |
| 5 |
|
Santos Laguna | 16 | 9 | 3 | 4 | 37:24 | 13 | 30 |
| 6 |
|
CF América | 16 | 8 | 4 | 4 | 29:18 | 11 | 28 |
| 7 |
|
Club Tijuana | 16 | 8 | 3 | 5 | 26:17 | 9 | 27 |
| 8 |
|
Cruz Azul | 16 | 7 | 3 | 6 | 15:23 | -8 | 24 |
| 9 |
|
CF Pachuca | 16 | 5 | 5 | 6 | 26:24 | 2 | 20 |
| 10 |
|
Pumas UNAM | 16 | 4 | 6 | 6 | 15:16 | -1 | 18 |
| 11 |
|
Puebla FC | 16 | 5 | 3 | 8 | 18:26 | -8 | 18 |
| 12 |
|
Deportivo Toluca | 16 | 5 | 3 | 8 | 13:23 | -10 | 18 |
| 13 |
|
Club Necaxa | 16 | 5 | 2 | 9 | 15:33 | -18 | 17 |
| 14 |
|
Gallos Blancos | 16 | 4 | 4 | 8 | 19:21 | -2 | 16 |
| 15 |
|
Club León | 16 | 3 | 5 | 8 | 17:26 | -9 | 14 |
| 16 |
|
Atlético San Luis | 16 | 2 | 6 | 8 | 13:31 | -18 | 12 |
| 17 |
|
Mazatlán FC | 16 | 1 | 3 | 12 | 6:36 | -30 | 6 |
| 18 |
|
FC Juárez | 16 | 1 | 2 | 13 | 9:37 | -28 | 5 |
| Playoffs |
