 |
 |
|
| 29/04/2022 | 23:00 | Atlético San Luis | - | Gallos Blancos | 3:1 (1:1) | |
| 30/04/2022 | 18:00 | Cruz Azul | - | Puebla FC | 3:1 (2:1) | |
| 01/05/2022 | 01:00 | CF Pachuca | - | Club Necaxa | 1:1 (0:1) | |
| 02/05/2022 | 00:00 | UANL Tigres | - | CF América | 1:1 (1:0) | |
| 18:00 | Atlas Guadalajara | - | Club León | 2:1 (0:0) | ||
| 23:00 | Deportivo Toluca | - | Pumas UNAM | 2:3 (1:1) | ||
| 03/05/2022 | 01:00 | Deportivo Guadalajara | - | CF Monterrey | 1:0 (0:0) | |
| 01:00 | Santos Laguna | - | Mazatlán FC | 1:0 (1:0) | ||
| 03:00 | Club Tijuana | - | FC Juárez | 3:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 17 | 14 | 1 | 2 | 51:13 | 38 | 43 |
| 2 |
|
Deportivo Guadalajara | 17 | 13 | 4 | 0 | 27:6 | 21 | 43 |
| 3 |
|
UANL Tigres | 17 | 11 | 6 | 0 | 43:11 | 32 | 39 |
| 4 |
|
CF América | 17 | 11 | 4 | 2 | 41:14 | 27 | 37 |
| 5 |
|
CF Pachuca | 17 | 9 | 3 | 5 | 28:22 | 6 | 30 |
| 6 |
|
Atlas Guadalajara | 17 | 7 | 6 | 4 | 27:25 | 2 | 27 |
| 7 |
|
Pumas UNAM | 17 | 6 | 4 | 7 | 18:17 | 1 | 22 |
| 8 |
|
Club Tijuana | 17 | 4 | 9 | 4 | 24:29 | -5 | 21 |
| 9 |
|
Cruz Azul | 17 | 6 | 3 | 8 | 22:30 | -8 | 21 |
| 10 |
|
Deportivo Toluca | 17 | 5 | 5 | 7 | 29:32 | -3 | 20 |
| 11 |
|
Atlético San Luis | 17 | 5 | 5 | 7 | 23:29 | -6 | 20 |
| 12 |
|
Gallos Blancos | 17 | 5 | 3 | 9 | 16:29 | -13 | 18 |
| 13 |
|
Santos Laguna | 17 | 5 | 2 | 10 | 17:29 | -12 | 17 |
| 14 |
|
Club Necaxa | 17 | 3 | 6 | 8 | 17:31 | -14 | 15 |
| 15 |
|
Mazatlán FC | 17 | 3 | 4 | 10 | 11:30 | -19 | 13 |
| 16 |
|
Club León | 17 | 3 | 4 | 10 | 18:40 | -22 | 13 |
| 17 |
|
Puebla FC | 17 | 3 | 3 | 11 | 11:25 | -14 | 12 |
| 18 |
|
FC Juárez | 17 | 3 | 2 | 12 | 18:29 | -11 | 11 |
| Playoffs |
