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| 1st(1st leg) | CF América | - | CF Pachuca | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | CF América | 0:1 (0:1) | ||
| 1st(1st leg): 30/11/2018 21:00 | 2nd (2nd leg): 04/12/2018 00:00 | Winner: CF América | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | UANL Tigres | 1:1 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Deportivo Guadalajara | 4:2 (3:2) | ||
| 1st(1st leg): 01/12/2018 02:00 | 2nd (2nd leg): 04/12/2018 02:00 | Winner: UANL Tigres | ||||
