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| 13/11/2021 | 17:15 | Atlas Guadalajara | - | UANL Tigres | 3:2 (1:1) | |
| 17:30 | Gallos Blancos | - | FC Juárez | 0:1 (0:0) | ||
| 17:30 | CF Monterrey | - | Club León | 2:2 (1:1) | ||
| 17:30 | Deportivo Toluca | - | CF Pachuca | 4:3 (3:0) | ||
| 17:30 | Santos Laguna | - | Deportivo Guadalajara | 0:2 (0:0) | ||
| 17:45 | Mazatlán FC | - | Club Necaxa | 1:3 (1:3) | ||
| 18:00 | Pumas UNAM | - | Club Tijuana | 2:1 (1:0) | ||
| 18:45 | CF América | - | Puebla FC | 6:1 (4:1) |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 8 | 6 | 1 | 1 | 29:15 | 14 | 19 |
| 2 |
|
CF Pachuca | 8 | 5 | 1 | 2 | 33:15 | 18 | 16 |
| 3 |
|
Deportivo Toluca | 9 | 4 | 1 | 4 | 17:16 | 1 | 13 |
| 4 |
|
FC Juárez | 8 | 4 | 1 | 3 | 11:20 | -9 | 13 |
| 5 |
|
Pumas UNAM | 8 | 3 | 3 | 2 | 17:13 | 4 | 12 |
| 6 |
|
Club Tijuana | 8 | 3 | 1 | 4 | 15:16 | -1 | 10 |
| 7 |
|
Puebla FC | 8 | 2 | 1 | 5 | 7:21 | -14 | 7 |
| 8 |
|
Cruz Azul | 8 | 1 | 3 | 4 | 15:23 | -8 | 6 |
| 9 |
|
Gallos Blancos | 7 | 1 | 2 | 4 | 5:10 | -5 | 5 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 8 | 7 | 0 | 1 | 22:7 | 15 | 21 |
| 2 |
|
Club Necaxa | 8 | 5 | 1 | 2 | 20:10 | 10 | 16 |
| 3 |
|
Atlas Guadalajara | 8 | 5 | 0 | 3 | 14:13 | 1 | 15 |
| 4 |
|
UANL Tigres | 8 | 4 | 2 | 2 | 19:11 | 8 | 14 |
| 5 |
|
Club León | 8 | 3 | 3 | 2 | 15:15 | 0 | 12 |
| 6 |
|
Santos Laguna | 8 | 3 | 1 | 4 | 10:13 | -3 | 10 |
| 7 |
|
CF Monterrey | 7 | 2 | 1 | 4 | 14:14 | 0 | 7 |
| 8 |
|
Mazatlán FC | 9 | 0 | 3 | 6 | 10:23 | -13 | 3 |
| 9 |
|
Atlético San Luis | 8 | 0 | 3 | 5 | 7:25 | -18 | 3 |
