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| 1st(1st leg) | Club Irapuato | - | Club León | 0:1 | ||
| 2nd (2nd leg) | Club León | - | Club Irapuato | 2:0 | ||
| 1st(1st leg): 23/11/2011 21:00 | 2nd (2nd leg): 27/11/2011 03:00 | Winner: Club León | ||||
| 1st(1st leg) | Estudiantes de Altamira | - | Correcaminos UAT | 2:1 | ||
| 2nd (2nd leg) | Correcaminos UAT | - | Estudiantes de Altamira | 1:0 | ||
| 1st(1st leg): 25/11/2011 00:00 | 2nd (2nd leg): 28/11/2011 00:00 | Winner: Correcaminos UAT | ||||
| 1st(1st leg) | Club Necaxa | - | Neza FC | 0:1 | ||
| 2nd (2nd leg) | Neza FC | - | Club Necaxa | 2:2 | ||
| 1st(1st leg): 25/11/2011 02:00 | 2nd (2nd leg): 27/11/2011 18:00 | Winner: Neza FC | ||||
