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| 1st(1st leg) | Correcaminos UAT | - | Mérida FC | 2:0 | ||
| 2nd (2nd leg) | Mérida FC | - | Correcaminos UAT | 1:1 | ||
| 1st(1st leg): 19/04/2012 01:00 | 2nd (2nd leg): 22/04/2012 01:00 | Winner: Correcaminos UAT | ||||
| 1st(1st leg) | Leones Negros | - | Club Necaxa | 1:1 | ||
| 2nd (2nd leg) | Club Necaxa | - | Leones Negros | 0:0 | ||
| 1st(1st leg): 19/04/2012 02:50 | 2nd (2nd leg): 21/04/2012 23:00 | Winner: Club Necaxa | ||||
| 1st(1st leg) | Lobos BUAP | - | Neza FC | 1:0 | ||
| 2nd (2nd leg) | Neza FC | - | Lobos BUAP | 0:0 | ||
| 1st(1st leg): 19/04/2012 22:00 | 2nd (2nd leg): 22/04/2012 18:00 | Winner: Lobos BUAP | ||||
