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| 1st(1st leg) | Reboceros de la Piedad | - | Estudiantes Tecos | 2:1 | ||
| 2nd (2nd leg) | Estudiantes Tecos | - | Reboceros de la Piedad | 1:3 | ||
| 1st(1st leg): 10/11/2012 21:00 | 2nd (2nd leg): 18/11/2012 02:00 | Winner: Reboceros de la Piedad | ||||
| 1st(1st leg) | Mérida FC | - | Lobos BUAP | 3:0 | ||
| 2nd (2nd leg) | Lobos BUAP | - | Mérida FC | 4:0 | ||
| 1st(1st leg): 11/11/2012 00:00 | 2nd (2nd leg): 17/11/2012 22:00 | Winner: Lobos BUAP | ||||
| 1st(1st leg) | Dorados de Sinaloa | - | Neza FC | 1:0 | ||
| 2nd (2nd leg) | Neza FC | - | Dorados de Sinaloa | 1:2 | ||
| 1st(1st leg): 12/11/2012 02:00 | 2nd (2nd leg): 18/11/2012 18:00 | Winner: Dorados de Sinaloa | ||||
