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| 1st(1st leg) | Cafetaleros de Tapachula | - | FC Juárez | 1:1 | ||
| 2nd (2nd leg) | FC Juárez | - | Cafetaleros de Tapachula | 1:0 | ||
| 1st(1st leg): 19/11/2015 00:00 | 2nd (2nd leg): 22/11/2015 01:00 | Winner: FC Juárez | ||||
| 1st(1st leg) | Atlante | - | Alebrijes de Oaxaca | 0:2 | ||
| 2nd (2nd leg) | Alebrijes de Oaxaca | - | Atlante | 1:4 | ||
| 1st(1st leg): 19/11/2015 02:00 | 2nd (2nd leg): 21/11/2015 23:00 | Winner: Atlante | ||||
| 1st(1st leg) | Murciélagos FC | - | Mineros de Zacatecas | 2:2 | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Murciélagos FC | 2:0 | ||
| 1st(1st leg): 19/11/2015 04:00 | 2nd (2nd leg): 22/11/2015 03:00 | Winner: Mineros de Zacatecas | ||||
