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| 1st(1st leg) | Club Celaya | - | Dorados de Sinaloa | 1:2 (0:2) | ||
| 2nd (2nd leg) | Dorados de Sinaloa | - | Club Celaya | 2:1 | ||
| 1st(1st leg): 08/04/2018 00:30 | 2nd (2nd leg): 15/04/2018 03:00 | Winner: Dorados de Sinaloa | ||||
| 1st(1st leg) | Cafetaleros de Tapachula | - | Mineros de Zacatecas | 3:1 (2:0) | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Cafetaleros de Tapachula | 4:2 | ||
| 1st(1st leg): 08/04/2018 02:30 | 2nd (2nd leg): 14/04/2018 22:30 | Winner: Cafetaleros de Tapachula | ||||
| 1st(1st leg) | Atlético Zacatepec | - | Alebrijes de Oaxaca | 1:1 | ||
| 2nd (2nd leg) | Alebrijes de Oaxaca | - | Atlético Zacatepec | 1:0 | ||
| 1st(1st leg): 09/04/2018 00:00 | 2nd (2nd leg): 16/04/2018 01:00 | Winner: Alebrijes de Oaxaca | ||||
| 1st(1st leg) | Atlante | - | Leones Negros | 2:0 | ||
| 2nd (2nd leg) | Leones Negros | - | Atlante | 4:0 | ||
| 1st(1st leg): 09/04/2018 02:00 | 2nd (2nd leg): 15/04/2018 18:00 | Winner: Leones Negros | ||||
