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| 1st(1st leg) | Club Celaya | - | Atlético San Luis | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético San Luis | - | Club Celaya | 2:1 (1:1) | ||
| 1st(1st leg): 18/04/2019 00:00 | 2nd (2nd leg): 21/04/2019 03:00 | Winner: Atlético San Luis | ||||
| 1st(1st leg) | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 1:0 (1:0) | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Alebrijes de Oaxaca | 1:0 (0:0) | ||
| 1st(1st leg): 18/04/2019 02:00 | 2nd (2nd leg): 21/04/2019 01:00 | |||||
| 1st(1st leg) | Venados FC | - | Atlético Zacatepec | 2:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Zacatepec | - | Venados FC | 1:0 (1:0) | ||
| 1st(1st leg): 19/04/2019 01:00 | 2nd (2nd leg): 21/04/2019 23:00 | Winner: Venados FC | ||||
| 1st(1st leg) | Dorados de Sinaloa | - | Cimarrones de Sonora | 1:0 (0:0) | ||
| 2nd (2nd leg) | Cimarrones de Sonora | - | Dorados de Sinaloa | 0:2 (0:0) | ||
| 1st(1st leg): 19/04/2019 03:00 | 2nd (2nd leg): 22/04/2019 02:00 | Winner: Dorados de Sinaloa | ||||
