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| 1st(1st leg) | Atlante | - | Club Celaya | 2:0 (2:0) | ||
| 2nd (2nd leg) | Club Celaya | - | Atlante | 3:3 (1:2) | ||
| 1st(1st leg): 27/04/2021 18:00 | 2nd (2nd leg): 30/04/2021 23:00 | Winner: Atlante | ||||
| 1st(1st leg) | Tepatitlán | - | Cimarrones de Sonora | 2:0 (0:0) | ||
| 2nd (2nd leg) | Cimarrones de Sonora | - | Tepatitlán | 1:4 (1:1) | ||
| 1st(1st leg): 28/04/2021 23:00 | 2nd (2nd leg): 02/05/2021 04:00 | Winner: Tepatitlán | ||||
| 1st(1st leg) | Tapatío | - | Mineros de Zacatecas | 0:1 (0:0) | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Tapatío | 2:1 (0:1) | ||
| 1st(1st leg): 29/04/2021 23:00 | 2nd (2nd leg): 02/05/2021 23:00 | Winner: Mineros de Zacatecas | ||||
