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| 1st(1st leg) | TM Fútbol Club | - | Dorados de Sinaloa | 1:0 (1:0) | ||
| 2nd (2nd leg) | Dorados de Sinaloa | - | TM Fútbol Club | 0:1 (0:1) | ||
| 1st(1st leg): 09/12/2021 00:30 | 2nd (2nd leg): 12/12/2021 03:00 | Winner: TM Fútbol Club | ||||
| 1st(1st leg) | Club Celaya | - | Atlante | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlante | - | Club Celaya | 2:2 (0:0) | ||
| 1st(1st leg): 10/12/2021 00:30 | 2nd (2nd leg): 12/12/2021 18:00 | Winner: Atlante | ||||
