 |
 |
|
| 1st(1st leg) | Saltillo FC | - | Alacranes de Durango | 0:1 (0:0) | ||
| 2nd (2nd leg) | Alacranes de Durango | - | Saltillo FC | 1:0 (1:0) | ||
| 1st(1st leg): 01/12/2021 22:00 | 2nd (2nd leg): 05/12/2021 02:00 | Winner: Alacranes de Durango | ||||
| 1st(1st leg) | Coras de Nayarit | - | Cafetaleros de Chiapas | 0:2 (0:1) | ||
| 2nd (2nd leg) | Cafetaleros de Chiapas | - | Coras de Nayarit | 3:3 (1:1) | ||
| 1st(1st leg): 02/12/2021 03:30 | 2nd (2nd leg): 05/12/2021 01:00 | Winner: Cafetaleros de Chiapas | ||||
| 1st(1st leg) | Yalmakan FC | - | Inter Playa | 0:2 (0:0) | ||
| 2nd (2nd leg) | Inter Playa | - | Yalmakan FC | 3:1 (1:0) | ||
| 1st(1st leg): 02/12/2021 20:00 | 2nd (2nd leg): 05/12/2021 20:00 | Winner: Inter Playa | ||||
