1st(1st leg) Alacranes de Durango - Cafetaleros de Chiapas 1:1 (1:0)
2nd (2nd leg) Cafetaleros de Chiapas - Alacranes de Durango 1:0 (0:0)
1st(1st leg): 16/04/2022 02:00 2nd (2nd leg): 24/04/2022 01:00 Winner: Cafetaleros de Chiapas
1st(1st leg) Coras de Nayarit - Inter Playa 1:2 (1:0)
2nd (2nd leg) Inter Playa - Coras de Nayarit 1:1 (1:0)
1st(1st leg): 16/04/2022 03:30 2nd (2nd leg): 22/04/2022 22:00 Winner: Inter Playa
1st(1st leg) Escorpiones - Mazorqueros 1:2 (1:0)
2nd (2nd leg) Mazorqueros - Escorpiones 7:0 (3:0)
1st(1st leg): 16/04/2022 22:00 2nd (2nd leg): 23/04/2022 23:30 Winner: Mazorqueros
1st(1st leg) Yalmakan FC - Tritones Vallarta 0:1 (0:0)
2nd (2nd leg) Tritones Vallarta - Yalmakan FC 1:1 (0:1)
1st(1st leg): 17/04/2022 22:00 2nd (2nd leg): 23/04/2022 22:30 Winner: Tritones Vallarta