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| 1st(1st leg) | Inter Playa | - | Tritones Vallarta | 1:0 (1:0) | ||
| 2nd (2nd leg) | Tritones Vallarta | - | Inter Playa | 1:1 (1:0) | ||
| 1st(1st leg): 24/03/2023 23:00 | 2nd (2nd leg): 01/04/2023 23:00 | Winner: Inter Playa | ||||
| 1st(1st leg) | Gavilanes de Matamoros | - | Tampico Madero | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tampico Madero | - | Gavilanes de Matamoros | 1:1 (1:0) | ||
| 1st(1st leg): 25/03/2023 22:00 | 2nd (2nd leg): 02/04/2023 03:00 | Winner: Gavilanes de Matamoros | ||||
| 1st(1st leg) | Deportivo Dongu | - | Chihuahua FC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Chihuahua FC | - | Deportivo Dongu | 2:1 (1:0) | ||
| 1st(1st leg): 25/03/2023 22:00 | 2nd (2nd leg): 01/04/2023 03:00 | Winner: Chihuahua FC | ||||
| 1st(1st leg) | Cafetaleros de Chiapas | - | Tecos Fútbol Club | 1:0 (1:0) | ||
| 2nd (2nd leg) | Tecos Fútbol Club | - | Cafetaleros de Chiapas | 1:1 (1:0) | ||
| 1st(1st leg): 26/03/2023 00:00 | 2nd (2nd leg): 01/04/2023 02:00 | Winner: Cafetaleros de Chiapas | ||||
