1st(1st leg) Santos F.C. - Tlaxcala Fútbol Club 0:1
2nd (2nd leg) Tlaxcala Fútbol Club - Santos F.C. 2:0
1st(1st leg): 27/11/2016 01:00 2nd (2nd leg): 04/12/2016 00:00 Winner: Tlaxcala Fútbol Club
1st(1st leg) Atlético Reynosa - Albinegros Orizaba 1:2
2nd (2nd leg) Albinegros Orizaba - Atlético Reynosa 0:0
1st(1st leg): 27/11/2016 01:45 2nd (2nd leg): 03/12/2016 18:00 Winner: Albinegros Orizaba
1st(1st leg) Cuervos de Ensenada - Pioneros de Cancún 0:0
2nd (2nd leg) Pioneros de Cancún - Cuervos de Ensenada 2:2
1st(1st leg): 27/11/2016 18:00 2nd (2nd leg): 03/12/2016 21:00 Winner: Cuervos de Ensenada
1st(1st leg) Club Irapuato - Club Tepatitlán 1:1
2nd (2nd leg) Club Tepatitlán - Club Irapuato 3:5
1st(1st leg): 27/11/2016 21:00 2nd (2nd leg): 03/12/2016 22:00 Winner: Club Irapuato