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| 1st(1st leg) | Deportivo Guadalajara II | - | Atlas Guadalajara II | 3:2 | ||
| 2nd (2nd leg) | Atlas Guadalajara II | - | Deportivo Guadalajara II | 0:0 | ||
| 1st(1st leg): 25/04/2018 16:00 | 2nd (2nd leg): 28/04/2018 17:30 | Winner: Deportivo Guadalajara II | ||||
| 1st(1st leg) | Gallos Blancos II | - | UANL Tigres II | 0:1 | ||
| 2nd (2nd leg) | UANL Tigres II | - | Gallos Blancos II | 1:2 | ||
| 1st(1st leg): 25/04/2018 23:00 | 2nd (2nd leg): 28/04/2018 17:30 | Winner: Gallos Blancos II | ||||
| 1st(1st leg) | Puebla FC II | - | CF América II | 3:1 | ||
| 2nd (2nd leg) | CF América II | - | Puebla FC II | 3:2 | ||
| 1st(1st leg): 26/04/2018 17:00 | 2nd (2nd leg): 29/04/2018 16:00 | Winner: Puebla FC II | ||||
| 1st(1st leg) | CD Veracruz II | - | Club Necaxa II | 1:0 | ||
| 2nd (2nd leg) | Club Necaxa II | - | CD Veracruz II | 5:1 | ||
| 1st(1st leg): 26/04/2018 23:00 | 2nd (2nd leg): 29/04/2018 17:00 | Winner: Club Necaxa II | ||||
