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| 1st(1st leg) | CF América II | - | Pumas UNAM II | 1:2 | ||
| 2nd (2nd leg) | Pumas UNAM II | - | CF América II | 1:2 | ||
| 1st(1st leg): 29/11/2017 16:00 | 2nd (2nd leg): 02/12/2017 21:30 | |||||
| 1st(1st leg) | Deportivo Guadalajara II | - | Club Tijuana III | 1:1 | ||
| 2nd (2nd leg) | Club Tijuana III | - | Deportivo Guadalajara II | 1:0 | ||
| 1st(1st leg): 29/11/2017 16:00 | 2nd (2nd leg): 02/12/2017 23:00 | Winner: Club Tijuana III | ||||
| 1st(1st leg) | Deportivo Toluca II | - | UANL Tigres II | 0:0 | ||
| 2nd (2nd leg) | UANL Tigres II | - | Deportivo Toluca II | 1:1 | ||
| 1st(1st leg): 29/11/2017 16:00 | 2nd (2nd leg): 02/12/2017 16:00 | Winner: Deportivo Toluca II | ||||
| 1st(1st leg) | CD Veracruz II | - | Monarcas Morelia II | 1:1 | ||
| 2nd (2nd leg) | Monarcas Morelia II | - | CD Veracruz II | 4:1 | ||
| 1st(1st leg): 30/11/2017 22:00 | 2nd (2nd leg): 03/12/2017 16:00 | Winner: Monarcas Morelia II | ||||
