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| 1st(1st leg) | Deportivo Toluca II | - | Deportivo Guadalajara II | 1:2 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara II | - | Deportivo Toluca II | 2:1 (0:1) | ||
| 1st(1st leg): 25/04/2019 16:00 | 2nd (2nd leg): 28/04/2019 16:00 | Winner: Deportivo Guadalajara II | ||||
| 1st(1st leg) | Pumas UNAM II | - | Club Necaxa II | 3:0 (2:0) | ||
| 2nd (2nd leg) | Club Necaxa II | - | Pumas UNAM II | 1:1 (0:0) | ||
| 1st(1st leg): 25/04/2019 16:00 | 2nd (2nd leg): 28/04/2019 17:00 | Winner: Pumas UNAM II | ||||
