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| 05/10/2018 | 16:00 | Pumas UNAM II | - | Cruz Azul Hidalgo | 0:1 (0:1) | |
| 16:00 | CF América II | - | Cocodrilos de Tabasco | 2:2 (2:2) | ||
| 06/10/2018 | 00:00 | Tecos Fútbol Club | - | Gavilanes de Matamoros | 0:1 (0:1) | |
| 01:30 | Dorados UACH | - | Cimarrones de Sonora II | 1:0 (1:0) | ||
| 02:00 | Coras de Nayarit | - | Murciélagos FC | 1:1 (1:1) | ||
| 02:00 | Alacranes de Durango | - | Tepatitlán | 1:2 (1:2) | ||
| 18:15 | Deportivo Toluca II | - | Reboceros de La Piedad | 1:0 (1:0) | ||
| 22:00 | Albinegros Orizaba | - | Yalmakan FC | 1:0 (1:0) | ||
| 22:00 | Tuxtla FC | - | Tuzos de la UAZ | 4:1 (4:1) | ||
| 22:00 | Loros UCOL | - | Club Necaxa II | 1:2 (1:2) | ||
| 22:00 | Inter Playa | - | Real Zamora | 2:1 (2:1) | ||
| 23:00 | Correcaminos UAT II | - | Monarcas Morelia II | 1:0 (1:0) | ||
| 23:00 | Pioneros de Cancún | - | Coyotes de Tlaxcala | 1:2 (1:2) | ||
| 23:00 | Club Irapuato | - | Sporting Canamy | 3:1 (3:1) | ||
| 23:00 | Pacific F. C. | - | Leones Negros II | 2:2 (2:2) | ||
| 07/10/2018 | 16:00 | Deportivo Guadalajara II | - | Atlético Reynosa | 2:1 (2:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Irapuato | 7 | 7 | 0 | 0 | 15:4 | 11 | 25 |
| 2 |
|
Tuxtla FC | 7 | 5 | 1 | 1 | 17:5 | 12 | 18 |
| 3 |
|
Tepatitlán | 7 | 5 | 1 | 1 | 13:6 | 7 | 18 |
| 4 |
|
Inter Playa | 7 | 5 | 1 | 1 | 13:7 | 6 | 18 |
| 5 |
|
Deportivo Guadalajara II | 7 | 4 | 2 | 1 | 10:5 | 5 | 18 |
| 6 |
|
Deportivo Toluca II | 7 | 4 | 3 | 0 | 15:9 | 6 | 17 |
| 7 |
|
Murciélagos FC | 7 | 4 | 2 | 1 | 13:7 | 6 | 17 |
| 8 |
|
Correcaminos UAT II | 7 | 3 | 4 | 0 | 10:4 | 6 | 16 |
| 9 |
|
Cruz Azul Hidalgo | 7 | 4 | 0 | 3 | 11:8 | 3 | 16 |
| 10 |
|
Gavilanes de Matamoros | 7 | 4 | 1 | 2 | 10:8 | 2 | 15 |
| 11 |
|
Dorados UACH | 7 | 3 | 2 | 2 | 8:10 | -2 | 15 |
| 12 |
|
Loros UCOL | 7 | 2 | 2 | 3 | 12:9 | 3 | 14 |
| 13 |
|
Coras de Nayarit | 7 | 3 | 3 | 1 | 10:7 | 3 | 14 |
| 14 |
|
Club Necaxa II | 7 | 2 | 4 | 1 | 6:7 | -1 | 13 |
| 15 |
|
Pumas UNAM II | 7 | 3 | 0 | 4 | 10:8 | 2 | 12 |
| 16 |
|
Tuzos de la UAZ | 7 | 2 | 4 | 1 | 10:9 | 1 | 12 |
| 17 |
|
Pacific F. C. | 7 | 2 | 3 | 2 | 11:12 | -1 | 11 |
| 18 |
|
Coyotes de Tlaxcala | 7 | 2 | 3 | 2 | 6:8 | -2 | 11 |
| 19 |
|
Tecos Fútbol Club | 7 | 1 | 2 | 4 | 6:10 | -4 | 10 |
| 20 |
|
Albinegros Orizaba | 7 | 2 | 2 | 3 | 4:6 | -2 | 9 |
| 21 |
|
CF América II | 7 | 1 | 4 | 2 | 9:13 | -4 | 9 |
| 22 |
|
Reboceros de La Piedad | 7 | 1 | 2 | 4 | 7:12 | -5 | 9 |
| 23 |
|
Pioneros de Cancún | 7 | 1 | 3 | 3 | 9:12 | -3 | 8 |
| 24 |
|
Real Zamora | 7 | 2 | 0 | 5 | 8:15 | -7 | 8 |
| 25 |
|
Monarcas Morelia II | 7 | 1 | 3 | 3 | 10:7 | 3 | 7 |
| 26 |
|
Leones Negros II | 7 | 1 | 3 | 3 | 10:13 | -3 | 7 |
| 27 |
|
Alacranes de Durango | 7 | 1 | 3 | 3 | 6:10 | -4 | 7 |
| 28 |
|
Atlético Reynosa | 7 | 0 | 3 | 4 | 4:8 | -4 | 7 |
| 29 |
|
Yalmakan FC | 7 | 1 | 2 | 4 | 3:7 | -4 | 7 |
| 30 |
|
Cocodrilos de Tabasco | 7 | 0 | 3 | 4 | 8:13 | -5 | 6 |
| 31 |
|
Sporting Canamy | 7 | 1 | 2 | 4 | 6:15 | -9 | 6 |
| 32 |
|
Cimarrones de Sonora II | 7 | 0 | 2 | 5 | 3:19 | -16 | 2 |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Playoffs | |
| Relegation |
