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| 1st(1st leg) | Club Irapuato | - | Inter Playa | 0:0 (0:0) | ||
| 2nd (2nd leg) | Inter Playa | - | Club Irapuato | 1:2 (1:1) | ||
| 1st(1st leg): 30/04/2021 02:00 | 2nd (2nd leg): 02/05/2021 22:00 | Winner: Club Irapuato | ||||
| 1st(1st leg) | Alacranes de Durango | - | Cruz Azul Hidalgo | 1:1 (1:1) | ||
| 2nd (2nd leg) | Cruz Azul Hidalgo | - | Alacranes de Durango | 1:1 (1:1) | ||
| 1st(1st leg): 30/04/2021 02:30 | 2nd (2nd leg): 02/05/2021 22:00 | |||||
