 |
 |
|
| 1st(1st leg) | Cafetaleros de Chiapas | - | Alacranes de Durango | 0:0 (0:0) | ||
| 2nd (2nd leg) | Alacranes de Durango | - | Cafetaleros de Chiapas | 0:0 (0:0) | ||
| 1st(1st leg): 17/04/2021 22:00 | 2nd (2nd leg): 24/04/2021 02:30 | |||||
| 1st(1st leg) | Colima FC | - | Inter Playa | 2:2 (1:1) | ||
| 2nd (2nd leg) | Inter Playa | - | Colima FC | 1:1 (0:1) | ||
| 1st(1st leg): 17/04/2021 23:00 | 2nd (2nd leg): 23/04/2021 22:00 | Winner: Inter Playa | ||||
| 1st(1st leg) | Gavilanes de Matamoros | - | Cruz Azul Hidalgo | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul Hidalgo | - | Gavilanes de Matamoros | 1:0 (0:0) | ||
| 1st(1st leg): 18/04/2021 01:00 | 2nd (2nd leg): 24/04/2021 22:00 | Winner: Cruz Azul Hidalgo | ||||
| 1st(1st leg) | Reboceros de La Piedad | - | Club Irapuato | 1:1 (0:1) | ||
| 2nd (2nd leg) | Club Irapuato | - | Reboceros de La Piedad | 4:1 (1:1) | ||
| 1st(1st leg): 18/04/2021 22:00 | 2nd (2nd leg): 25/04/2021 01:00 | Winner: Club Irapuato | ||||
