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| 1st(1st leg) | Deportivo Toluca | - | Cruz Azul | 2:1 (2:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Deportivo Toluca | 1:1 (0:1) | ||
| 1st(1st leg): 03/05/2006 21:00 | 2nd (2nd leg): 06/05/2006 23:00 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Club San Luis | - | Atlante | 1:0 (0:0) | ||
| 2nd (2nd leg) | Atlante | - | Club San Luis | 0:0 (0:0) | ||
| 1st(1st leg): 04/05/2006 02:30 | 2nd (2nd leg): 07/05/2006 01:00 | Winner: Club San Luis | ||||
| 1st(1st leg) | Monarcas Morelia | - | CF Pachuca | 2:1 (1:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | Monarcas Morelia | 3:1 (2:0) | ||
| 1st(1st leg): 05/05/2006 01:00 | 2nd (2nd leg): 07/05/2006 23:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | Jaguares Chiapas | 2:3 (1:1) | ||
| 2nd (2nd leg) | Jaguares Chiapas | - | Deportivo Guadalajara | 2:4 (1:2) | ||
| 1st(1st leg): 05/05/2006 02:45 | 2nd (2nd leg): 07/05/2006 21:00 | Winner: Deportivo Guadalajara | ||||
