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| 1st(1st leg) | Club San Luis | - | CF América | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Club San Luis | 4:1 (3:0) | ||
| 1st(1st leg): 18/11/2010 01:00 | 2nd (2nd leg): 21/11/2010 01:00 | Winner: CF América | ||||
| 1st(1st leg) | Pumas UNAM | - | Cruz Azul | 1:2 (1:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | Pumas UNAM | 0:2 (0:1) | ||
| 1st(1st leg): 18/11/2010 03:00 | 2nd (2nd leg): 20/11/2010 23:00 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 1:1 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 3:3 (2:1) | ||
| 1st(1st leg): 19/11/2010 00:00 | 2nd (2nd leg): 21/11/2010 22:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Jaguares Chiapas | - | Santos Laguna | 1:1 (1:1) | ||
| 2nd (2nd leg) | Santos Laguna | - | Jaguares Chiapas | 1:0 (0:0) | ||
| 1st(1st leg): 19/11/2010 02:00 | 2nd (2nd leg): 22/11/2010 00:00 | Winner: Santos Laguna | ||||
