1st(1st leg) CF Pachuca - CF América 1:3 (0:2)
2nd (2nd leg) CF América - CF Pachuca 0:1 (0:1)
1st(1st leg): 03/05/2012 02:30 2nd (2nd leg): 06/05/2012 00:00 Winner: CF América
1st(1st leg) Club Tijuana - CF Monterrey 1:2 (0:1)
2nd (2nd leg) CF Monterrey - Club Tijuana 2:2 (1:1)
1st(1st leg): 03/05/2012 04:30 2nd (2nd leg): 06/05/2012 02:00 Winner: CF Monterrey
1st(1st leg) Jaguares Chiapas - Santos Laguna 3:4 (2:2)
2nd (2nd leg) Santos Laguna - Jaguares Chiapas 2:1 (2:1)
1st(1st leg): 04/05/2012 01:00 2nd (2nd leg): 07/05/2012 00:00 Winner: Santos Laguna
1st(1st leg) UANL Tigres - Monarcas Morelia 1:0 (1:0)
2nd (2nd leg) Monarcas Morelia - UANL Tigres 1:4 (0:0)
1st(1st leg): 04/05/2012 03:00 2nd (2nd leg): 07/05/2012 02:00 Winner: UANL Tigres