1st(1st leg) CF América - Club León 4:1 (3:1)
2nd (2nd leg) Club León - CF América 2:1 (1:0)
1st(1st leg): 26/11/2015 01:00 2nd (2nd leg): 29/11/2015 02:06 Winner: CF América
1st(1st leg) UANL Tigres - Chiapas FC 2:1 (1:0)
2nd (2nd leg) Chiapas FC - UANL Tigres 0:1 (0:1)
1st(1st leg): 26/11/2015 03:00 2nd (2nd leg): 29/11/2015 00:00 Winner: UANL Tigres
1st(1st leg) CD Veracruz - Pumas UNAM 0:1 (0:1)
2nd (2nd leg) Pumas UNAM - CD Veracruz 1:0 (1:0)
1st(1st leg): 29/11/2015 18:00 2nd (2nd leg): 29/11/2015 18:00 Winner: Pumas UNAM
1st(1st leg) Puebla FC - Deportivo Toluca 0:1 (0:0)
2nd (2nd leg) Deportivo Toluca - Puebla FC 1:0 (0:0)
1st(1st leg): 29/11/2015 23:00 2nd (2nd leg): 29/11/2015 23:00 Winner: Deportivo Toluca