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| 1st(1st leg) | Puebla FC | - | Club León | 2:1 (2:1) | ||
| 2nd (2nd leg) | Club León | - | Puebla FC | 2:0 (2:0) | ||
| 1st(1st leg): 26/11/2020 01:00 | 2nd (2nd leg): 29/11/2020 01:00 | Winner: Club León | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF América | 1:0 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Guadalajara | 1:2 (0:1) | ||
| 1st(1st leg): 26/11/2020 03:06 | 2nd (2nd leg): 29/11/2020 03:06 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | UANL Tigres | - | Cruz Azul | 1:3 (0:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | UANL Tigres | 0:1 (0:0) | ||
| 1st(1st leg): 27/11/2020 01:00 | 2nd (2nd leg): 30/11/2020 00:30 | Winner: Cruz Azul | ||||
| 1st(1st leg) | CF Pachuca | - | Pumas UNAM | 0:1 (0:1) | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF Pachuca | 0:0 (0:0) | ||
| 1st(1st leg): 27/11/2020 03:06 | 2nd (2nd leg): 29/11/2020 18:00 | Winner: Pumas UNAM | ||||
