 |
 |
|
| 10/09/2021 | 17:45 | Puebla FC | - | Atlético San Luis | 1:3 (1:2) | |
| 18:30 | FC Juárez | - | Cruz Azul | 5:0 (2:0) | ||
| 20:45 | Club Tijuana | - | Santos Laguna | 3:0 (1:0) | ||
| 11/09/2021 | 17:00 | CF América | - | Mazatlán FC | 2:1 (0:0) | |
| 17:15 | UANL Tigres | - | Club León | 1:1 (1:1) | ||
| 17:30 | Atlas Guadalajara | - | CF Monterrey | 4:0 (2:0) | ||
| 12/09/2021 | 17:30 | Gallos Blancos | - | Club Necaxa | 1:1 (0:0) | |
| 17:30 | Pumas UNAM | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| 13/09/2021 | 15:30 | CF Pachuca | - | Deportivo Toluca | 2:2 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 8 | 6 | 2 | 0 | 24:12 | 12 | 20 |
| 2 |
|
CF América | 8 | 6 | 1 | 1 | 17:8 | 9 | 19 |
| 3 |
|
Atlas Guadalajara | 8 | 5 | 2 | 1 | 15:8 | 7 | 17 |
| 4 |
|
Club Tijuana | 8 | 4 | 1 | 3 | 15:11 | 4 | 13 |
| 5 |
|
CF Pachuca | 8 | 3 | 3 | 2 | 14:10 | 4 | 12 |
| 6 |
|
Mazatlán FC | 8 | 3 | 3 | 2 | 12:11 | 1 | 12 |
| 7 |
|
UANL Tigres | 8 | 3 | 3 | 2 | 8:7 | 1 | 12 |
| 8 |
|
Club León | 8 | 3 | 3 | 2 | 10:11 | -1 | 12 |
| 9 |
|
Cruz Azul | 8 | 3 | 3 | 2 | 8:15 | -7 | 12 |
| 10 |
|
FC Juárez | 8 | 3 | 2 | 3 | 16:12 | 4 | 11 |
| 11 |
|
Deportivo Toluca | 8 | 3 | 2 | 3 | 10:9 | 1 | 11 |
| 12 |
|
Deportivo Guadalajara | 8 | 2 | 4 | 2 | 16:10 | 6 | 10 |
| 13 |
|
Gallos Blancos | 8 | 2 | 2 | 4 | 6:8 | -2 | 8 |
| 14 |
|
Atlético San Luis | 8 | 2 | 2 | 4 | 13:22 | -9 | 8 |
| 15 |
|
Pumas UNAM | 8 | 1 | 4 | 3 | 10:14 | -4 | 7 |
| 16 |
|
CF Monterrey | 8 | 0 | 4 | 4 | 6:13 | -7 | 4 |
| 17 |
|
Santos Laguna | 8 | 0 | 3 | 5 | 6:15 | -9 | 3 |
| 18 |
|
Puebla FC | 8 | 0 | 2 | 6 | 10:20 | -10 | 2 |
| Playoffs |
