1st(1st leg) Santos Laguna - Atlas Guadalajara 0:1 (0:1)
2nd (2nd leg) Atlas Guadalajara - Santos Laguna 3:1 (1:0)
1st(1st leg): 19/05/2022 01:00 2nd (2nd leg): 21/05/2022 15:00 Winner: Atlas Guadalajara