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| 1st(1st leg) | CF América | - | CF Monterrey | 1:2 (1:2) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF América | 3:2 (2:0) | ||
| 1st(1st leg): 18/11/2020 17:00 | 2nd (2nd leg): 21/11/2020 15:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Pumas UNAM | - | Atlas Guadalajara | 0:2 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Pumas UNAM | 0:2 (0:1) | ||
| 1st(1st leg): 18/11/2020 18:00 | 2nd (2nd leg): 21/11/2020 15:00 | |||||
| 1st(1st leg) | Club León | - | Cruz Azul | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Club León | 2:2 (2:1) | ||
| 1st(1st leg): 18/11/2020 21:45 | 2nd (2nd leg): 21/11/2020 15:00 | Winner: Cruz Azul | ||||
| 1st(1st leg) | UANL Tigres | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | UANL Tigres | 4:1 (1:1) | ||
| 1st(1st leg): 19/11/2020 16:30 | 2nd (2nd leg): 22/11/2020 15:00 | Winner: Deportivo Guadalajara | ||||
