 |
 |
|
| 1st(1st leg) | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| 1st(1st leg): 02/12/2021 17:00 | 2nd (2nd leg): 05/12/2021 17:00 | Winner: Santos Laguna | ||||
|
|
|
| 1st(1st leg) | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| 1st(1st leg): 02/12/2021 17:00 | 2nd (2nd leg): 05/12/2021 17:00 | Winner: Santos Laguna | ||||
