1st(1st leg) UANL Tigres - Cruz Azul 0:0 (0:0)
2nd (2nd leg) Cruz Azul - UANL Tigres 0:0 (0:0)
1st(1st leg): 24/11/2021 15:00 2nd (2nd leg): 27/11/2021 15:00
1st(1st leg) Atlas Guadalajara - Santos Laguna 0:1 (0:1)
2nd (2nd leg) Santos Laguna - Atlas Guadalajara 0:1 (0:1)
1st(1st leg): 25/11/2021 15:00 2nd (2nd leg): 28/11/2021 17:00