 |
 |
|
|
| 22/10/2021 | 15:30 | Mazatlán FC | - | Gallos Blancos | 4:0 (0:0) | |
| 23/10/2021 | 15:00 | CF América | - | UANL Tigres | 2:1 (1:1) | |
| 15:00 | Deportivo Guadalajara | - | Cruz Azul | 0:1 (0:0) | ||
| 15:00 | Puebla FC | - | Club León | 2:1 (1:0) | ||
| 15:00 | CF Monterrey | - | Club Necaxa | 5:1 (2:0) | ||
| 24/10/2021 | 15:00 | Pumas UNAM | - | Club Tijuana | 4:0 (2:0) | |
| 16:00 | Atlético San Luis | - | Atlas Guadalajara | 0:2 (0:0) | ||
| 17:00 | Santos Laguna | - | Deportivo Toluca | 3:0 (0:0) | ||
| 25/10/2021 | 18:00 | CF Pachuca | - | FC Juárez | 6:0 (4:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 15 | 8 | 4 | 3 | 31:20 | 11 | 28 |
| 2 |
|
Cruz Azul | 15 | 6 | 7 | 2 | 12:7 | 5 | 25 |
| 3 |
|
Atlas Guadalajara | 15 | 7 | 3 | 5 | 21:19 | 2 | 24 |
| 4 |
|
CF América | 15 | 6 | 5 | 4 | 22:18 | 4 | 23 |
| 5 |
|
Deportivo Toluca | 15 | 7 | 2 | 6 | 20:19 | 1 | 23 |
| 6 |
|
Deportivo Guadalajara | 15 | 7 | 2 | 6 | 22:22 | 0 | 23 |
| 7 |
|
Pumas UNAM | 15 | 6 | 3 | 6 | 26:23 | 3 | 21 |
| 8 |
|
Mazatlán FC | 15 | 6 | 3 | 6 | 29:29 | 0 | 21 |
| 9 |
|
Club León | 15 | 6 | 3 | 6 | 16:17 | -1 | 21 |
| 10 |
|
Puebla FC | 15 | 5 | 6 | 4 | 25:27 | -2 | 21 |
| 11 |
|
UANL Tigres | 15 | 6 | 2 | 7 | 20:19 | 1 | 20 |
| 12 |
|
Atlético San Luis | 15 | 6 | 2 | 7 | 23:24 | -1 | 20 |
|
Club Necaxa | 15 | 5 | 5 | 5 | 23:24 | -1 | 20 | |
| 14 |
|
CF Pachuca | 15 | 4 | 7 | 4 | 22:17 | 5 | 19 |
| 15 |
|
CF Monterrey | 15 | 5 | 4 | 6 | 24:20 | 4 | 19 |
| 16 |
|
Club Tijuana | 15 | 4 | 5 | 6 | 22:27 | -5 | 17 |
| 17 |
|
Gallos Blancos | 15 | 4 | 5 | 6 | 18:23 | -5 | 17 |
| 18 |
|
FC Juárez | 15 | 1 | 4 | 10 | 10:31 | -21 | 7 |
| Playoffs |
