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| 01/12/2021 | 12:00 | Sileks Kratovo | - | FK Bregalnica Štip | 5:4 (0:0, 1:1) pso | |
| 12:00 | KF Shkëndija 79 | - | FC Struga | 3:4 (0:0, 0:0) pso | ||
| 12:00 | Makedonija GP | - | KF Shkupi | 4:1 (0:0, 0:0) pso | ||
| 15/12/2021 | 12:00 | FK Pelister | - | Vardar Skopje | 3:2 (0:0, 0:0) pso |
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| 01/12/2021 | 12:00 | Sileks Kratovo | - | FK Bregalnica Štip | 5:4 (0:0, 1:1) pso | |
| 12:00 | KF Shkëndija 79 | - | FC Struga | 3:4 (0:0, 0:0) pso | ||
| 12:00 | Makedonija GP | - | KF Shkupi | 4:1 (0:0, 0:0) pso | ||
| 15/12/2021 | 12:00 | FK Pelister | - | Vardar Skopje | 3:2 (0:0, 0:0) pso |
