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| 1st(1st leg) | Diriangén FC | - | CD Walter Ferretti | 3:2 (0:2) | ||
| 2nd (2nd leg) | CD Walter Ferretti | - | Diriangén FC | 1:3 (0:3) | ||
| 1st(1st leg): 29/11/2020 01:00 | 2nd (2nd leg): 06/12/2020 22:00 | Winner: Diriangén FC | ||||
| 1st(1st leg) | Chinandega | - | Real Estelí FC | 2:2 (0:1) | ||
| 2nd (2nd leg) | Real Estelí FC | - | Chinandega | 1:0 (1:0) | ||
| 1st(1st leg): 29/11/2020 21:00 | 2nd (2nd leg): 07/12/2020 01:00 | Winner: Real Estelí FC | ||||
