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| 21/05/2022 | 18:30 | VV UNA | - | HVV Hollandia | 3:4 (1:2) | |
| 22/05/2022 | 13:00 | ADO '20 | - | HSC'21 | 4:1 (1:1) | |
| 13:00 | Quick Den Haag | - | RKSV Groene Ster | 0:0 (0:0) | ||
| 13:00 | Blauw Geel '38 | - | RKVV DEM | 2:1 (2:0) | ||
| 13:00 | RKVV Westlandia | - | JOS Watergraafsmeer | 2:2 (2:0) | ||
| 13:00 | Unitas Gorinchem | - | VV Dongen | 1:2 (1:2) | ||
| 13:00 | VV Gemert | - | VV Hoogland | 2:3 (2:0) | ||
| 13:30 | EVV | - | OFC Oostzaan | 0:2 (0:0) | ||
| 01/06/2022 | 13:30 | OSS '20 | - | USV Hercules | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 31 | 17 | 5 | 9 | 62:46 | 16 | 56 |
| 2 |
|
VV Gemert | 31 | 15 | 10 | 6 | 70:51 | 19 | 55 |
| 3 |
|
ADO '20 | 31 | 16 | 5 | 10 | 57:41 | 16 | 53 |
| 4 |
|
USV Hercules | 31 | 16 | 4 | 11 | 64:40 | 24 | 52 |
| 5 |
|
RKSV Groene Ster | 31 | 14 | 8 | 9 | 44:42 | 2 | 50 |
| 6 |
|
VV UNA | 31 | 15 | 4 | 12 | 56:48 | 8 | 49 |
| 7 |
|
OSS '20 | 31 | 14 | 7 | 10 | 55:43 | 12 | 48 |
| 8 |
|
Quick Den Haag | 31 | 14 | 5 | 12 | 47:37 | 10 | 47 |
| 9 |
|
VV Dongen | 31 | 12 | 10 | 9 | 51:42 | 9 | 46 |
| 10 |
|
HSC'21 | 31 | 13 | 4 | 14 | 54:46 | 8 | 43 |
| 11 |
|
Blauw Geel '38 | 31 | 13 | 4 | 14 | 52:51 | 1 | 43 |
| 12 |
|
Unitas Gorinchem | 31 | 12 | 5 | 14 | 39:54 | -15 | 41 |
| 13 |
|
RKVV DEM | 31 | 11 | 5 | 15 | 33:49 | -16 | 38 |
| 14 |
|
JOS Watergraafsmeer | 31 | 11 | 5 | 15 | 51:62 | -11 | 36 |
| 15 |
|
VV Hoogland | 31 | 9 | 5 | 17 | 36:62 | -26 | 32 |
| 16 |
|
HVV Hollandia | 31 | 9 | 4 | 18 | 35:52 | -17 | 31 |
| 17 |
|
EVV | 31 | 7 | 10 | 14 | 32:55 | -23 | 31 |
| 18 |
|
RKVV Westlandia | 31 | 7 | 8 | 16 | 36:53 | -17 | 29 |
| Promotion | |
| Playoffs | |
| Relegation |
