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| 04/02/2022 | 18:30 | FC Twente | - | Feyenoord | 2:1 (1:0) | |
| 18:30 | SBV Excelsior | - | vv Alkmaar | 2:1 (1:1) | ||
| 18:30 | ADO Den Haag | - | sc Heerenveen | 1:0 (1:0) | ||
| 28/02/2022 | 18:30 | PSV Eindhoven | - | AFC Ajax | 1:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AFC Ajax | 15 | 11 | 1 | 3 | 41:15 | 26 | 34 |
| 2 |
|
FC Twente | 15 | 10 | 3 | 2 | 60:22 | 38 | 33 |
| 3 |
|
PSV Eindhoven | 15 | 8 | 2 | 5 | 23:20 | 3 | 26 |
| 4 |
|
Feyenoord | 15 | 7 | 4 | 4 | 20:16 | 4 | 25 |
| 5 |
|
ADO Den Haag | 16 | 5 | 5 | 6 | 26:24 | 2 | 20 |
| 6 |
|
PEC Zwolle | 15 | 6 | 2 | 7 | 25:24 | 1 | 20 |
| 7 |
|
vv Alkmaar | 15 | 4 | 1 | 10 | 18:39 | -21 | 13 |
| 8 |
|
sc Heerenveen | 15 | 2 | 5 | 8 | 13:30 | -17 | 11 |
| 9 |
|
SBV Excelsior | 15 | 2 | 3 | 10 | 17:53 | -36 | 9 |
| Champions League |
