1st(1st leg) Go Ahead Eagles - FC Den Bosch 2:2 (1:1)
2nd (2nd leg) FC Den Bosch - Go Ahead Eagles 0:1 (0:0)
1st(1st leg): 19/05/2019 11:15 2nd (2nd leg): 22/05/2019 17:30 Winner: Go Ahead Eagles
1st(1st leg) RKC Waalwijk - SBV Excelsior 2:1 (0:0)
2nd (2nd leg) SBV Excelsior - RKC Waalwijk 1:1 (0:1)
1st(1st leg): 19/05/2019 13:30 2nd (2nd leg): 22/05/2019 17:30 Winner: RKC Waalwijk
1st(1st leg) TOP Oss - Sparta Rotterdam 0:2 (0:0)
2nd (2nd leg) Sparta Rotterdam - TOP Oss 3:0 (1:0)
1st(1st leg): 19/05/2019 15:45 2nd (2nd leg): 22/05/2019 19:45 Winner: Sparta Rotterdam
1st(1st leg) SC Cambuur - De Graafschap 1:1 (1:1)
2nd (2nd leg) De Graafschap - SC Cambuur 2:0 (2:0)
1st(1st leg): 19/05/2019 19:00 2nd (2nd leg): 22/05/2019 19:45 Winner: De Graafschap