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| 1st(1st leg) | De Graafschap | - | FC Eindhoven | 1:1 (0:1) | ||
| 2nd (2nd leg) | FC Eindhoven | - | De Graafschap | 3:1 (3:1) | ||
| 1st(1st leg): 09/05/2022 19:00 | 2nd (2nd leg): 13/05/2022 19:00 | Winner: FC Eindhoven | ||||
| 1st(1st leg) | NAC Breda | - | ADO Den Haag | 1:2 (0:1) | ||
| 2nd (2nd leg) | ADO Den Haag | - | NAC Breda | 2:1 (0:0) | ||
| 1st(1st leg): 10/05/2022 17:45 | 2nd (2nd leg): 14/05/2022 15:30 | Winner: ADO Den Haag | ||||
| 1st(1st leg) | SBV Excelsior | - | Roda JC Kerkrade | 2:2 (2:0) | ||
| 2nd (2nd leg) | Roda JC Kerkrade | - | SBV Excelsior | 0:2 (0:0, 0:0, 0:2) aet | ||
| 1st(1st leg): 10/05/2022 19:00 | 2nd (2nd leg): 14/05/2022 19:00 | Winner: SBV Excelsior | ||||
