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| 1st(1st leg) | ADO Den Haag | - | FC Eindhoven | 2:1 (2:0) | ||
| 2nd (2nd leg) | FC Eindhoven | - | ADO Den Haag | 1:2 (0:2) | ||
| 1st(1st leg): 17/05/2022 19:00 | 2nd (2nd leg): 21/05/2022 15:30 | Winner: ADO Den Haag | ||||
| 1st(1st leg) | SBV Excelsior | - | Heracles Almelo | 3:0 (1:0) | ||
| 2nd (2nd leg) | Heracles Almelo | - | SBV Excelsior | 1:3 (1:0) | ||
| 1st(1st leg): 18/05/2022 17:45 | 2nd (2nd leg): 21/05/2022 19:00 | Winner: SBV Excelsior | ||||
