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| 06/01/2018 | 13:30 | Knockbreda FC | - | Institute FC Drumahoe | 0:2 (0:2) | |
| 13:30 | Queen's University Belfast | - | Dundela FC | 0:1 (0:1) | ||
| 13:30 | Lurgan Celtic | - | Glentoran FC | 1:2 (0:2) | ||
| 15:00 | Larne FC | - | Dergview FC | 3:0 (0:0) | ||
| 15:00 | Carrick Rangers | - | Glenavon FC | 1:3 (0:1, 1:1) aet | ||
| 15:00 | Coleraine FC | - | Lisburn Distillery | 7:0 (3:0) | ||
| 15:00 | Crusaders FC | - | Maiden City Soccer | 2:0 (1:0) | ||
| 15:00 | Dungannon Swifts | - | Limavady United | 4:0 (2:0) | ||
| 15:00 | Ballinamallard United FC | - | Immaculata FC | 4:2 (1:0) | ||
| 15:00 | Cliftonville FC | - | Warrenpoint Town | 4:3 (1:1, 2:2) aet | ||
| 15:00 | Linfield FC | - | Glebe Rangers | 5:0 (1:0) | ||
| 15:00 | Loughgall FC | - | PSNI FC | 4:1 (2:1) | ||
| 15:00 | Ballymena United | - | Moyola Park FC | 4:0 (2:0) | ||
| 15:00 | Newry City FC | - | H&W Welders | 2:0 (0:0) | ||
| 15:00 | Portadown FC | - | Ballyclare Comrades | 1:2 (1:0, 1:1) aet | ||
| 15:00 | Ards FC | - | Crumlin Star | 4:1 (2:1) |
