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| 1st(1st leg) | Costa del Este FC | - | Independiente de La Chorrera | 1:2 (0:1) | ||
| 2nd (2nd leg) | Independiente de La Chorrera | - | Costa del Este FC | 0:0 (0:0) | ||
| 1st(1st leg): 13/12/2020 21:00 | 2nd (2nd leg): 16/12/2020 21:00 | Winner: Independiente de La Chorrera | ||||
| 1st(1st leg) | San Francisco FC | - | Tauro FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Tauro FC | - | San Francisco FC | 2:2 (1:0) | ||
| 1st(1st leg): 14/12/2020 21:00 | 2nd (2nd leg): 17/12/2020 21:00 | Winner: San Francisco FC | ||||
