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| 1st(1st leg) | Alianza | - | Atlético Chiriquí | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Chiriquí | - | Alianza | 1:1 (0:0) | ||
| 1st(1st leg): 15/05/2022 02:00 | 2nd (2nd leg): 22/05/2022 02:00 | Winner: Alianza | ||||
| 1st(1st leg) | Tauro FC | - | Sporting San Miguelito | 1:2 (0:1) | ||
| 2nd (2nd leg) | Sporting San Miguelito | - | Tauro FC | 0:0 (0:0) | ||
| 1st(1st leg): 16/05/2022 00:30 | 2nd (2nd leg): 23/05/2022 00:00 | Winner: Sporting San Miguelito | ||||
