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| 1st(1st leg) | Veraguas Club Deportivo | - | UD Universitario | 0:0 (0:0) | ||
| 2nd (2nd leg) | UD Universitario | - | Veraguas Club Deportivo | 2:0 (0:0, 0:0) aet | ||
| 1st(1st leg): 15/05/2021 22:00 | 2nd (2nd leg): 23/05/2021 01:00 | Winner: UD Universitario | ||||
| 1st(1st leg) | Sporting San Miguelito | - | Plaza Amador | 0:1 (0:1) | ||
| 2nd (2nd leg) | Plaza Amador | - | Sporting San Miguelito | 1:1 (0:0) | ||
| 1st(1st leg): 17/05/2021 00:00 | 2nd (2nd leg): 24/05/2021 00:00 | Winner: Plaza Amador | ||||
