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| 1st(1st leg) | Veraguas Club Deportivo | - | Herrera FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Herrera FC | - | Veraguas Club Deportivo | 1:0 (0:0) | ||
| 1st(1st leg): 28/11/2021 00:00 | 2nd (2nd leg): 05/12/2021 23:00 | Winner: Herrera FC | ||||
| 1st(1st leg) | Alianza | - | Tauro FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tauro FC | - | Alianza | 1:0 (1:0) | ||
| 1st(1st leg): 30/11/2021 00:00 | 2nd (2nd leg): 05/12/2021 22:00 | Winner: Tauro FC | ||||
