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| 1st(1st leg) | Sporting San Miguelito | - | Independiente de La Chorrera | 1:1 (0:1) | ||
| 2nd (2nd leg) | Independiente de La Chorrera | - | Sporting San Miguelito | 1:0 (1:0) | ||
| 1st(1st leg): 30/10/2022 00:00 | 2nd (2nd leg): 06/11/2022 00:00 | Winner: Independiente de La Chorrera | ||||
| 1st(1st leg) | UD Universitario | - | Árabe Unido | 1:0 (0:0) | ||
| 2nd (2nd leg) | Árabe Unido | - | UD Universitario | 0:0 (0:0) | ||
| 1st(1st leg): 30/10/2022 23:00 | 2nd (2nd leg): 06/11/2022 21:00 | Winner: UD Universitario | ||||
