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| 26/07/2022 | 21:00 | Primavera de Curuguaty | - | Benjamín Aceval | 1:6 | |
| 23:30 | 2 de Mayo | - | Sportivo Iteño | 3:4 | ||
| 27/07/2022 | 23:30 | San Lorenzo | - | Libertad | 1:2 | |
| 28/07/2022 | 23:30 | General Caballero ZC | - | Sportivo Luqueño | 1:0 | |
| 02/08/2022 | 21:00 | Obrero de Capitán Bado | - | Sportivo Ameliano | 0:5 | |
| 23:30 | Sportivo Trinidense | - | Guaireña FC | 2:3 | ||
| 03/08/2022 | 21:00 | Sport Colombia | - | Club Nacional | 1:3 | |
| 23:30 | Club Rubio Ñu | - | Cerro Porteño | 1:0 | ||
| 04/08/2022 | 21:00 | Fernando de la Mora | - | Sol de América | 4:5 pso | |
| 23:30 | Colonial | - | Club Olimpia | 0:9 | ||
| 09/08/2022 | 21:00 | Atlético Tembetary | - | Deportivo Capiatá | 2:0 | |
| 23:30 | River Plate | - | 12 de Octubre de Itauguá | 1:4 | ||
| 10/08/2022 | 19:45 | Atlético Colegiales | - | Resistencia SC | 1:2 | |
| 23:30 | Cristóbal Colón JAS | - | Guaraní | 0:1 | ||
| 11/08/2022 | 21:00 | Deportivo Juventud | - | Tacuary | 4:5 pso | |
| 23:30 | Fulgencio Yegros | - | General Caballero DJLM | 0:3 |
